medchemlab ucm

THE WORLD IS NO PERFECT... BUT LET'S TRY MEDICINAL CHEMISTRY FOR A BETTER WORLD

Erlenmenyer

Research

The main research interests of our group are the development of new pharmacological agents and the identification of therapeutic targets.
We are carrying out several research lines on four fields of major relevance for human health nowadays: cancer, CNS-associated diseases, infectious diseases and aging.
We are also implementing phenotypic approaches to identify therapeutic targets and to find new molecular entities both in mammalian cells and in the human microbiota. In this part of the work, our objective is to develop methodologies that generate de novo information about the physiological and/or pathological state of the biological system under study. To achieve this goal we are combining medicinal chemistry, chemical biology and proteomics, expecting that the integration of these methodologies will provide us with a reliable and complete picture of the complexity of the biological system under study.

outreaching

Latest Publications

Check out our latest publications:

JACS Au 2024, doi 10.1021/jacsau.3c00682

S. Algar, H. Vázquez-Villa, P. Aguilar-Garrido, M.A. Navarro-Aguadero, M. Velasco-Estévez, A. Sánchez-Merino, I. Arribas-Álvarez, A. Paradela, R.L. Giner-Arroyo, J. Tamargo-Azpilicueta, I. Díaz-Moreno, J. Martínez-López, M. Gallardo, M.L. López-Rodríguez, B. Benhamú

Bioorg. Chem. 2024, 142, 106967-106977

J. Macicior, D. Fernandez, S. Ortega-Gutierrez

JACS Au 2023, 3, 868-878

A. Canales, J. Sastre, J.M. Orduña, C.M. Spruit, J. Pérez-Castells, G. Domínguez, K.M. Bouwman, R. van der Woude, F.J. Cañada, C.M. Nycholat, J.C. Paulson, G.-J. Boons, J. Jiménez-Barbero, R.P. de Vries

J. Am. Chem. Soc. 2023, 145, 19824–19831

C. Mycroft, G. Dal Poggetto, T.M. Barbosa, C.F. Tormena, M. Nilsson, G.A. Morris, L. Castañar

About Our Group

The Medicinal Chemistry Laboratory at Universidad Complutense de Madrid (Spain) is made up of full and associate professors, tenure-track and postdoctoral researchers, and graduate and pre-graduate students. The staff includes scientists with different areas of expertise, including organic chemistry, medicinal chemistry, chemical biology, biochemistry, cell and structural biology, and computational modeling.