PUBLICATIONS
2004-2000
Benzimidazole derivatives. Part 5: design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands
M.L. López-Rodríguez, B. Benhamú, M.J. Morcillo, I. Tejada, D. Avila, I. Marco, L. Schiapparelli, D. Frechilla, J. Del Río
Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake
S. Ortega-Gutiérrez, E.G. Hawkins, A. Viso, M.L.. López-Rodríguez, B.F. Cravatt
Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis--a difficult issue to handle
C.J. Fowler, G. Tiger, A. Ligresti, M.L. López-Rodríguez, V. Di Marzo
Synthesis and structure-activity relationships of a new model of arylpiperazines. Part 7: Study of the influence of lipophilic factors at the terminal amide fragment on 5-HT1A affinity/selectivity
M.L. López-Rodríguez, D. Ayala, A. Viso, B. Benhamú, R.F. de La Pradilla, F. Zarza, J.A. Ramos
Fine-tuned aminal cleavage: a concise route to differentially protected enantiopure syn-alpha,beta-diamino Esters
A. Viso, R. Fernández de la Pradilla, M.L. López-Rodríguez, A. García, A. Flores, M. Alonso
Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study
L. Ruiz-Llorente, S. Ortega-Gutiérrez, A. Viso, M.G. Sánchez, A. M. Sánchez, C. Fernández, J.A. Ramos, C. Hillard, M.A. Lasunción, M.L. López-Rodríguez, I. Díaz-Laviada
CB1 cannabinoid receptors and on-demand defense against excitotoxicity
G. Marsicano, S. Goodenough, K. Monory, H. Hermann, M. Eder, A,. Cannich, S.C. Azad, M.G. Cascio, S. Ortega-Gutiérrez, M. van der Stelt, M.L. López-Rodriguez, E. Casanova, G. Schütz, W. Zieglgänsberger, V. Di Marzo, C. Behl, B. Lutz
Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists
M.L. López-Rodríguez, B. Benhamú, M. Murcia, E. Alvaro, M. Campillo, L. Pardo
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives
M.L. López-Rodríguez, E. Porras, M.J. Morcillo, B.Benhamú, L.J Soto, J.L. Lavandera, J.A. Ramos, M. Olivella, M. Campillo, L. Pardo
VR1 receptor modulators as potential drugs for neuropathic pain
M.L. López-Rodríguez, A. Viso, S. Ortega-Gutiérrez
Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin
C.J. Fowler, G. Tiger, M.L. López-Rodríguez, A. Viso, S. Ortega-Gutiérrez, J.A. Ramos
Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands
M.L. López-Rodríguez, B. Benhamú, M.J. Morcillo, I. Tejada, D. Avila, I. Marco, L. Schiapparelli, D. Frechilla, J. Del Río
Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors
M.L. López-Rodríguez, A. Viso, S. Ortega-Gutiérrez, C.J. Fowler, G. Tiger, E. de Lago, J. Fernández-Ruiz, J. A. Ramos
Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase
M.L. López-Rodríguez, A. Viso, S. Ortega-Gutiérrez, C.J. Fowler, G. Tiger, E. de Lago, J. Fernández-Ruiz, J.A. Ramos
Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist
M.L. López-Rodríguez, M.J. Morcillo, E. Fernández, B. Benhamú, I. Tejada, D. Ayala, A. Viso, M. Olivella, L. Pardo, M. Delgado, J. Manzanares, J.A. Fuentes
New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists
D. Pascual, R. Girón, A. Alsasua, B. Benhamú, M.L. López-Rodríguez, M.I. Martín
Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists
M.L López-Rodríguez, M. Murcia, B. Benhamú, A. Viso, M. Campillo, L. Pardo
UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide
E. de Lago, J. Fernández-Ruiz, S. Ortega-Gutiérrez, A. Viso, M.L. López-Rodríguez, J.A. Ramos
Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor
M.L. López-Rodríguez, B. Vicente, X. Deupi, S. Barrondo, M. Olivella, M.J. Morcillo, B. Behamú, J.A. Ballesteros, J. Sallés, L. Pardo
5-HT(4) receptor antagonists: structure-affinity relationships and ligand-receptor interactions
M.L. López-Rodriguez, B. Benhamú, M.J. Morcillo, M. Murcia, A. Viso, M. Campillo, L. Pardob
Arylpiperazine derivatives acting at 5-HT1A receptors
M.L. López-Rodríguez, D. Ayala, B. Benhamú, M.J. Morcillo, A. Viso
Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin
M.L. López-Rodríguez, M. Murcia, B. Benhamú, M. Olivella, M. Campillo, L. Pardo
Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors
M.L. López-Rodríguez, A. Viso, S. Ortega-Gutiérrez, I. Lastres-Becker, S. González, J. Fernández-Ruiz, J.A. Ramos
3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT(4) receptor
M.L. López-Rodríguez, M. Murcia, B. Benhamú, A. Viso, M. Campillo, L. Pardo
Biochemical, electrophysiological and neurohormonal studies with B-20991, a selective 5-HT1A receptor agonist
A.G. Caicoya, M.E. Beneytez, M. Delgado, J. Manzanares, M.L. López-Rodríguez, B. Benhamú, M.J. Morcillo, M.A. Pozo, F.J. Rubia, J.A. Fuentes
Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT1A/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition
M.L. López-Rodríguez, M.J. Morcillo, E. Fernández, M.L. Rosado, L. Pardo, K. Schaper
Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT1A alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed 5-HT1A/d(2) antagonist properties
M.L. López-Rodríguez, M.J. Morcillo, E. Fernández, E. Porra, L. Orensanz, M.E. Beneytez, J. Manzanares, J.A. Fuentes
Pd(0) Amination of benzimidazoles as an efficient method towards new (benzimidazolyl) piperazines
M.L. López Rodríguez, B. Benhamú, D. Ayala, J.L. Rominguera, M. Murcia, J.A. Ramos, A. Viso
First pharmacophoric hypothesis for 5-HT7 antagonism
M.L. López Rodríguez, E. Porras, B. Benhamú, J.A. Ramos, M.J. Morcillo, J.L. Lavandera