PUBLICATIONS
2014-2010
A reversible and selective inhibitor of monoacylglycerol lipase ameliorates multiple sclerosis
G. Hernández-Torres, M. Cipriano, E. Hedén, E. Björklund, A. Canales, D. Zian, A. Feliú, M. Mecha, C. Guaza, C.J. Fowler, S. Ortega-Gutiérrez, M.L. López-Rodríguez
The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo
R.A. Medina, H. Vázquez-Villa, J.C. Gómez-Tamayo, B. Benhamú, M. Martín-Fontecha, T. de la Fuente, G. Caltabiano, P.B. Hedlund, L. Pardo, M.L. López-Rodríguez
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer’s disease
B. Benhamú, M. Martín-Fontecha, H. Vázquez-Villa, L. Pardo, M.L. López-Rodríguez
The expression of cannabinoid receptor 1 is significantly increased in atopic patients
M. Martín-Fontecha, T. Eiwegger, T. Jartti, A. Rueda-Zubiaurre, K. Tiringer, J. Stepanow, T. Puhakka, B. Rückert, S. Ortega-Gutiérrez, M.L. López-Rodríguez, M. Akdis, C.A. Akdis and O. Palomares
The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
A.C. Campos, Z. Ortega, J. Palazuelos, M.V. Fogaça, D.C. Aguiar, J. Díaz-Alonso, S. Ortega-Gutiérrez, H. Vázquez-Villa, F.A. Moreira, M. Guzmán, I. Galve-Roperh and F.S. Guimarães
Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor blockade
L. Bellocchio, E. Soria-Gómez, C. Quarta, M. Metna-Laurent, P. Cardinal, E. Binder, A. Cannich, A. Delamarre, M. Häring, M. Martín-Fontecha, D. Vega, T. Leste-Lasserre, D. Bartsch, K. Monory, B. Lutz, F. Chaouloff, U. Pagotto, M. Guzman, D. Cota, G. Marsicano
Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ
L.B. Ruiz-Avila, S. Huecas, M. Artola, A. Vergoñós, E. Ramírez-Aportela, E. Cercenado, I. Barasoain, H. Vázquez-Villa, M. Martín-Fontecha, P. Chacón, M.L. López-Rodríguez and J.M. Andreu
New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo
M. Valhondo, I. Marco, M. Martín-Fontecha, H. Vázquez-Villa, J.A. Ramos, R. Berkels, T. Lauterbach, B. Benhamú and M.L. López-Rodríguez
Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery
A. Arevalo-Martin, D. Garcia-Ovejero, Y. Sierra-Palomares, B. Paniagua-Torija, I. Gonzalez-Gil, S. Ortega-Gutierrez and E. Molina-Holgado
Chemical probes for the recognition of cannabinoid receptors in native systems
L. Martín-Couce, M. Martín-Fontecha, O. Palomares, L. Mestre, A. Cordomí, M. Hernangomez, S. Palma, L. Pardo, C. Guaza, M.L. López-Rodríguez and S. Ortega-Gutiérrez
New synthetic inhibitors of fatty acid synthase with anticancer activity
C. Turrado, T. Puig, J. García-Cárceles, M. Artola, B. Benhamú, S. Ortega-Gutiérrez, J. Relat, G. Oliveras, A. Blancafort, D. Haro, P.F. Marrero, R. Colomer, and M.L. López-Rodríguez
Mitochondrial CB1 receptors regulate neuronal energy metabolism
G. Bénard, F. Massa, N. Puente, J. Lourenço, L. Bellocchio, E. Soria-Gómez, I. Matias, A. Delamarre, M. Metna-Laurent, A. Cannich, E. Hebert-Chatelain, C. Mulle, S. Ortega-Gutiérrez, M. Martín-Fontecha, M. Klugmann, S. Guggenhuber, B. Lutz, J. Gertsch, F. Chaouloff, M.L. López-Rodríguez, P. Grandes, R. Rossignol and G. Marsicano
Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase / fatty acid amide hydrolase inhibitors
J.A. Cisneros, E. Björklund, I. González-Gil, Y. Hu, A. Canales, F.J. Medrano, A. Romero, S. Ortega-Gutiérrez, C.J. Fowler, and M.L. López-Rodríguez
A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines
T. Puig, H. Aguilar, S. Cufí, G. Oliveras, C. Turrado, S. Ortega-Gutiérrez, B. Benhamú, M.L. López-Rodríguez, A. Urruticoechea and R. Colomer
New serotonin 5-HT1A receptor agonists with neuroprotective effect against ischemic cell damage
I. Marco, M. Valhondo, M. Martín-Fontecha, H. Vázquez-Villa, J. del Río, A. Planas, O. Sagredo, J.A. Ramos, I.R. Torrecillas, L. Pardo, D. Frechilla, B. Benhamú and M.L. López-Rodríguez
Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons
W.R. Marrs, E.A. Horne, S. Ortega-Gutiérrez, J.A. Cisneros, C. Xu, Y.H. Lin, G.G. Muccioli, M.L. López-Rodríguez and N. Stella
Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors
L. Martín-Couce, M. Martín-Fontecha, S. Capolicchio, M.L. López-Rodríguez and S. Ortega-Gutiérrez
Development of non-peptide ligands of growth factor receptor-bound protein 2-Src homology 2 domain using molecular modeling and NMR spectroscopy
A.L. Orcajo-Rincón, S. Ortega-Gutiérrez, P. Serrano, I.R. Torrecillas, K. Wüthrich, M. Campillo, L. Pardo, A. Viso, B. Benhamú and M.L. López-Rodríguez
The importance of solvation in the design of ligands targeting membrane proteins
A. González, M. Murcia, B. Benhamú, M. Campillo, M.L. López-Rodríguez and L. Pardo
The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation
J.M. Andreu, C. Schaffner-Barbero, S. Huecas, D. Alonso, M.L. López-Rodríguez, L.B. Ruiz-Avila, R. Núñez-Ramirez, O. LLorca and A.J. Martín-Galiano
Development of fluorescent ligands for the human 5-HT1A receptor
D. Alonso, H. Vázquez-Villa, A.M. Gamo, M.F. Martínez-Esperón, M. Tortosa, A. Viso, R. Fernández de la Pradilla, E. Junquera, E. Aicart, M. Martín-Fontecha, B. Benhamú, M.L. López-Rodríguez and S. Ortega-Gutiérrez
Development of molecular probes for the human 5-HT6 receptor
H. Vázquez-Villa, J.A. González-Vera, B. Benhamú, A. Viso, R. Fernández de la Pradilla, E. Junquera, E. Aicart, M.L. López-Rodríguez and S. Ortega-Gutiérrez
Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation
T. de la Fuente, M. Martín-Fontecha, J. Sallander, B. Benhamú, M. Campillo, R.A. Medina, L.P. Pellissier, S. Claeysen, A. Dumuis, L. Pardo and M.L. López-Rodríguez
The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation
O. Gómez, A. Arévalo-Martín, D. García-Ovejero, S. Ortega-Gutiérrez, J.A. Cisneros, G. Almazán, M.A. Sánchez, F. Molina-Holgado and E. Molina-Holgado