PUBLICATIONS
2019-2015
Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
M.J. Bueno, V. Jimenez-Renard, S. Samino, J. Capellades, A. Junza, M.L. López-Rodríguez, J. Garcia-Carceles, I. Lopez-Fabuel, J.P. Bolaños, N.S. Chandel, O. Yanes, R. Colomer, M. Quintela-Fandino
A potent isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor improves survival in Ras-driven acute myeloid leukemia
N.I. Marin-Ramos, M. Balabasquer, F.J. Ortega-Nogales, I.R. Torrecillas, A. Gil-Ordoñez, B. Marcos-Ramiro, P. Aguilar-Garrido, I. Cushman, A. Romero, F. J. Medrano, C. Gajate, F. Mollinedo, M.R. Philips, M. Campillo, M. Gallardo, M. Martín-Fontecha, M.L. López-Rodríguez, S. Ortega-Gutierrez
Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons
A. Ruiz-Calvo, R. Bajo-Grañeras, I.B. Maroto, D. Zian, G.F. Grabner, E. García-Taboada, E. Resel, R. Zechner, R. Zimmermann, S. Ortega-Gutiérrez, I. Galve-Roperh, L. Bellocchio, M. Guzmán
Blocking Ras inhibition as an antitumor strategy
N.I. Marín-Ramos, S. Ortega-Gutiérrez, M.L. López-Rodríguez
Monoacylglycerol lipase (MAGL) as a promising therapeutic target
A. Gil-Ordóñez, M. Martín-Fontecha, S. Ortega-Gutiérrez, M.L. López-Rodríguez
Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination
A. Manterola, A. Bernal-Chico, R. Cipriani, M. Canedo-Antelo, A. Moreno-García, M. Martín-Fontecha, F. Pérez-Cerdá, M.V. Sánchez-Gómez, S. Ortega-Gutiérrez, J.M. Brown, K.L. Hsu, B.F. Cravatt, C. Matute, S. Mato
Development of a fluorescent bodipy probe for visualization of the serotonin 5-HT1A receptor in native cells of the immune system
G. Hernandez-Torres, E. Enriquez-Palacios, M. Mecha, A. Feliu, A. Rueda-Zubiaurre, A. Angelina, L. Martin-Cruz, M. Martín-Fontecha, O. Palomares, C. Guaza, E. Peña-Cabrera, M.L. López-Rodríguez, S. Ortega-Gutiérrez
2-AG limits Theiler´s virus induced acute neuroinflammation by modulating microglia and promoting MDSCs
M. Mecha, A. Feliú, I. Machín, C. Cordero, F. Carrillo-Salinas, L. Mestre, G. Hernández-Torres, S. Ortega-Gutiérrez, M.L. López-Rodríguez, F. de Castro, D. Clemente, C. Guaza
Unique pharmacological properties of serotonergic G-protein coupled receptors from cestodes
F. Camicia, A.M. Celentano, M.E. Johns, J.D. Chan, L. Maldonado, H. Vaca, N. Di Siervi, L. Kamentezky, A.M. Gamo, S. Ortega-Gutierrez, M. Martin-Fontecha, C. Davio, J.S. Marchant , M.C. Rosenzvit
Publication: PLoS Negl. Trop. Dis. doi: 10.1371/journal.pntd.0006267
A fluorescent probe to unravel functional features of cannabinoid receptor CB1 in human blood and tonsil immune system cells
M. Martín-Fontecha, A. Angelina, B. Rückert, A. Rueda-Zubiaurre, L. Martín-Cruz, W. van de Veen, M. Akdis, S. Ortega-Gutiérrez, M.L. López-Rodríguez, C.A. Akdis, O. Palomares
A positive allosteric modulator of the serotonin 5-HT2C receptor for obesity
J. García Cárceles, J.M. Decara, H. Vázquez-Villa, R. Rodríguez, E. Codesido, J. Cruces, J.M. Brea, M.I. Loza, F. Alén, J. Botta, P.J. McCormick, J.A. Ballesteros, B. Benhamú, F. Rodríguez de Fonseca, M.L. López-Rodrígue
2-arachidonoylglycerol reduces proteoglycans and enhances remyelination in a progressive model of demyelination
A. Feliu, B.I. del Río, F.J. Carrillo-Salinas, G. Hernández-Torres, L. Mestre, N. Puente, S. Ortega-Gutiérrez, M.L. López-Rodríguez, P. Grandes, M. Mecha, C. Guaza
Ligand chain length drives activation of lipid G protein-coupled receptors
A. Troupiotis-Tsaïlaki, J. Zachmann, I. González-Gil, A. Gonzalez, S. Ortega-Gutiérrez, M.L. López-Rodríguez, L. Pardo, C. Govaerts
A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding
J.A. González-Vera, R.A. Medina, M. Martín-Fontecha, A. Gonzalez, T. de la Fuente, H. Vázquez-Villa, J. García-Cárceles, J. Botta, P.J. McCormick, B. Benhamú, L. Pardo, M.L. López-Rodríguez
Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells
R. Wagner, G. Stübiger, D. Veigel, M. Wuczkowski, P. Lanzerstorfer, J. Weghuber, E. Karteris, K. Nowikovsky, N. Wilfinger-Lutz, C.F. Singer, R. Colomer, B. Benhamú, M.L. López-Rodríguez, P. Valent, T.W. Grunt
Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells
O. Palomares, M. Akdis, M. Martín-Fontecha, C.A. Akdis
Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma
N. Rodriguez-Perez, E. Schiavi, R. Frei, R. Ferstl, P. Wawrzyniak, S. Smolinska, M. Sokolowska, N.A. Sievi, M. Kohler, P. Schmid-Grendelmeier, D. Michalovich, K.D. Simpson, E.M. Hessel, M. Jutel, M. Martin-Fontecha, O. Palomares, C.A. Akdis, L. O’Mahony
Development of a nucleotide exchange inhibitor that impairs Ras oncogenic signaling
N.I. Marin-Ramos, C. Piñar, H. Vazquez-Villa, M. Martín-Fontecha, A. Gonzalez, A. Canales, S. Algar, P.P. Mayo, J. Jimenez-Barbero, C. Gajate, F. Mollinedo, L. Pardo, S. Ortega-Gutierrez, A. Viso, M.L. López-Rodríguez
The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors
M. Artola, L.B. Ruiz-Avila, E. Ramírez-Aportela, R.F. Martínez, L. Araujo-Bazán, H. Vázquez-Villa, M. Martín-Fontecha, M.A. Oliva, A. J. Martín-Galiano, P. Chacón, M.L. López-Rodríguez, J.M. Andreu, S. Huecas
A cannabinoid link between mitochondria and memory
E. Hebert-Chatelain, T. Desprez, R. Serrat, L. Bellocchio, E. Soria-Gomez, A. Busquets-Garcia, A.C. Pagano Zottola, A. Delamarre, A. Cannich, P. Vincent, M. Varilh, L.M. Robin, G. Terral, M.D. García-Fernández, M. Colavita, W. Mazier, F. Drago, N. Puente, L. Reguero, I. Elezgarai, J.W. Dupuy, D. Cota, M.L. Lopez-Rodriguez, G. Barreda-Gómez, F. Massa, P. Grandes, G. Bénard, G. Marsicano
A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington's disease
J.L. López-Sendón Moreno, J. García Caldentey, P. Trigo Cubillo, C. Ruiz Romero, G. García Ribas, M.A. Alonso Arias, M.J. García de Yébenes, R.M. Tolón, I. Galve-Roperh, O. Sagredo, S. Valdeolivas, E. Resel, S. Ortega-Gutierrez, M.L. García-Bermejo, J. Fernández Ruiz, M. Guzmán, J. García de Yébenes Prous
Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors
A.M. Gamo, J.A. González-Vera, A. Rueda-Zubiaurre, D. Alonso, H. Vázquez-Villa, L. Martín-Couce, Ó. Palomares, J.A. López, M. Martín-Fontecha, B. Benhamú, M.L. López-Rodríguez, S. Ortega-Gutiérrez
Endocannabinoids drive the acquisition of an alternative phenotype in microglia
M. Mecha, A. Feliú, F.J. Carrillo-Salinas, A. Rueda-Zubiaurre, S. Ortega-Gutiérrez, R.G. de Sola, C. Guaza
Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action
M. Artola, L.B. Ruiz-Avila, A. Vergoñós, S. Huecas, L. Araujo-Bazán, M. Martín-Fontecha, H. Vázquez-Villa, C. Turrado, E. Ramírez-Aportela, A. Hoegl, M. Nodwell, I. Barasoain, P. Chacón, S.A. Sieber, J.M. Andreu, M.L. López-Rodríguez
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells
D. Veigel, R. Wagner, G. Stübiger, M. Wuczkowski, M. Filipits, R. Horvat, B. Benhamú, M.L. López-Rodríguez, A. Leisser, P. Valent, M. Grusch, F.G. Hegardt, J. García, D. Serra, N. Auersperg, R. Colomer, T.W. Grunt
The status of the lysophosphatidic acid receptor type 1 (LPA1R)
I. González-Gil, D. Zian, H. Vázquez-Villa, S. Ortega-Gutiérrez, M.L. López-Rodríguez
A basal tone of 2-arachidonoylglycerol contributes to early oligodendrocyte progenitor proliferation by activating phosphatidylinositol 3-kinase (PI3K)/AKT and the mammalian target of rapamycin (MTOR) pathways
O. Gomez, M.A. Sanchez-Rodriguez, S. Ortega-Gutierrez, H. Vazquez-Villa, C. Guaza, F. Molina-Holgado, E. Molina-Holgado
Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer
E. Pérez-Gómez, C. Andradas, M.M. Caffarel, S. Blasco-Benito, E. García-Taboada, M. Villa-Morales, E. Moreno, S. Hamann, E. Martín-Villar, J.M. Flores, A. Wenners, I. Alkatout, W. Klapper, C. Röcken, P. Bronsert, E. Stickeler, A. Staebler, M. Bauer, N. Arnold, J. Soriano, M. Pérez-Martínez, D. Megías, G. Moreno-Bueno, S. Ortega-Gutiérrez, M. Artola, H. Vázquez-Villa, M. Quintanilla, J. Fernández-Piqueras, E.I. Canela, P.J. McCormick, M. Guzmán, C. Sánchez
Auranofin efficacy against MDR Streptococcus pneumoniae and Staphylococcus aureus infections
L. Aguinagalde, R. Díez-Martínez, J. Yuste, I. Royo, C. Gil, I. Lasa, M. Martín-Fontecha, N.I. Marín-Ramos, C. Ardanuy, J. Liñares, P. García, E. García, J.M. Sánchez-Puelles
New inhibitors of angiogenesis with antitumor activity in vivo
N.I. Marín-Ramos, D. Alonso, S. Ortega-Gutierrez, F.J. Ortega-Nogales, M. Balabasquer, H. Vazquez-Villa, C. Andradas, S. Blasco-Benito, E. Pérez-Gómez, A. Canales, J. Jimenez-Barbero, A. Marquina, J. Moscoso del Prado, C. Sánchez, M. Martín-Fontecha, M.L. López-Rodríguez