PUBLICATIONS
2020-CURRENT
Cancer-stem-cell phenotype-guided discovery of a microbiota-inspired synthetic compound targeting NPM1 for leukemia
S. Algar, H. Vázquez-Villa, P. Aguilar-Garrido, M.A. Navarro-Aguadero, M. Velasco-Estévez, A. Sánchez-Merino, I. Arribas-Álvarez, A. Paradela, R.L. Giner-Arroyo, J. Tamargo-Azpilicueta, I. Díaz-Moreno, J. Martínez-López, M. Gallardo, M.L. López-Rodríguez, B. Benhamú
A new fluorescent probe for the visualization of progerin
J. Macicior, D. Fernandez, S. Ortega-Gutierrez
Rapid Measurement of Heteronuclear Coupling Constants in Complex NMR Spectra
C. Mycroft, G. Dal Poggetto, T.M. Barbosa, C.F. Tormena, M. Nilsson, G.A. Morris, L. Castañar
Revealing the Specificity of Human H1 Influenza A Viruses to Complex N-Glycans
A. Canales, J. Sastre, J.M. Orduña, C.M. Spruit, J. Pérez-Castells, G. Domínguez, K.M. Bouwman, R. van der Woude, F.J. Cañada, C.M. Nycholat, J.C. Paulson, G.-J. Boons, J. Jiménez-Barbero, R.P. de Vries
2-(Fluoromethoxy)-4'-(S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an orally bioavailable positive allosteric modulator of the human dopamine D1 receptor for Parkinson’s disease
J. García-Cárceles, H. Vázquez-Villa, J. Brea, D. Ladron de Guevara-Miranda, G. Cincilla, M. Sánchez-Martínez, A. Sánchez-Merino, S. Algar, M.T. de los Frailes, R.S. Roberts, J.A. Ballesteros, F. Rodríguez de Fonseca, B. Benhamú, M.I. Loza, M.L. López-Rodríguez
Novel antagonist of the type 2 lysophosphatidic acid receptor (LPA2), UCM-14216, ameliorates spinal cord injury in mice
N. Khiar-Fernández, D. Zian, H. Vázquez-Villa, R.F. Martínez, A. Escobar-Peña, R. Foronda-Sainz, M. Ray, M. Puigdomenech-Poch, G. Cincilla, M. Sánchez-Martínez, Y. Kihara, J. Chun, R. López-Vales, M.L. López-Rodríguez, S. Ortega-Gutiérrez
New trends in aging drug discovery
B. Benhamú, M. Martín-Fontecha, H. Vázquez-Villa, M.L. López-Rodríguez, S. Ortega-Gutiérrez
Discovery of V-0219: A small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor toward oral treatment for “Diabesity”
J.M. Decara, H. Vázquez-Villa, J. Brea, M. Alonso, R.K. Srivastava, L. Orio, F. Alén, J. Suárez, E. Baixeras, J. García-Cárceles, A. Escobar-Peña, B. Lutz, R. Rodríguez, E. Codesido, F.J. Garcia-Ladona, T.A. Bennett, J.A. Ballesteros, J. Cruces, M.I. Loza, B. Benhamú, F. Rodríguez de Fonseca, M.L. López-Rodríguez
The search for antibacterial inhibitors targeting cell division protein FtsZ at its nucleotide and allosteric binding sites
J.M. Andreu, S. Huecas, L. Araújo-Bazán, H. Vázquez-Villa, M. Martín-Fontecha
Isoprenylcysteine carboxylmethyltransferase-based therapy for Hutchinson–Gilford progeria syndrome
B. Marcos-Ramiro, A. Gil-Ordóñez, N.I. Marín-Ramos, F. J. Ortega-Nogales, M. Balabasquer, P. Gonzalo, N. Khiar-Fernández, L. Rolas, A. Barkaway, S. Nourshargh, V. Andrés, M. Martín-Fontecha, M.L. López-Rodríguez, S. Ortega-Gutiérrez
Small-molecule therapeutic perspectives for the treatment of progeria
J. Macicior, B. Marcos-Ramiro, S. Ortega-Gutiérrez
Targeting the FtsZ allosteric binding site with a novel fluorescence polarization screen, cytological and structural approaches for antibacterial discovery
S. Huecas, L. Araújo-Bazán, F.M. Ruiz, L.B. Ruiz-Ávila, R.F. Martínez, A. Escobar-Peña, M. Artola, H. Vázquez-Villa, M. Martín-Fontecha, C. Fernández-Tornero, M.L. López-Rodríguez, J.M. Andreu
The pharmacological or genetic blockade of endogenous de novo fatty acid synthesis does not increase the uptake of exogenous lipids in ovarian cancer cells
T.W. Grunt, L. Lemberger, R. Colomer, M.L. López-Rodríguez, R. Wagner
Chemistry for the identification of therapeutic targets: Recent advances and future directions
N. Khiar-Fernandez, J. Macicior, B. Marcos-Ramiro, S. Ortega-Gutierrez
The cannabinoid WIN55212-2 restores rhinovirus-induced epithelial barrier disruption
A. Angelina, M. Martín-Fontecha, B. Rückert, P. Wawrzyniak, M. Pérez-Diego, J. López-Abente, M. Akdis, C.A. Akdis, O. Palomares
Membrane disruption, but not metabolic rewiring, is the key mechanism of anticancer action of FASN inhibitors: a multi-omics analysis in ovarian cancer
T.W. Grunt, A. Slany, M. Semkova, R. Colomer, M.L. López-Rodríguez, M. Wuczkowski, R. Wagner, C. Gerner, G. Stübiger
Serum endocannabinoid levels in suicide attempters: A pilot study
J. Herranz-Herrer, E. Gil-Benito, T. Ponte-López, S. Ortega-Gutiérrez, J. Macicior, S. Rosado-Garcia, A.J. Sánchez-López, H. Blasco-Fontecilla
A novel agonist of the type 1 lysophosphatidic acid receptor (LPA1), UCM-05194, shows efficacy in neuropathic pain amelioration
I. Gonzalez-Gil, D. Zian, H. Vázquez-Villa, G. Hernandez-Torres, R.F. Martinez, N. Khiar-Fernandez, R. Rivera, Y. Kihara, I. Devesa, S. Mathivanan, C. Rosell del Valle, E. Zambrana-Infantes, M. Puigdomenech, G. Cincilla, M. Sanchez-Martinez, F. Rodriguez de Fonseca, A. Ferrer-Montiel, J. Chun, R. Lopez-Vales, M.L. López-Rodríguez, S. Ortega-Gutierrez
Glucose metabolism links astroglial mitochondria to cannabinoid effects
D. Jimenez-Blasco, A. Busquets-Garcia, E. Hebert-Chatelain, R. Serrat, C. Vicente-Gutierrez, C. Ioannidou, P. Gómez-Sotres, I. Lopez-Fabuel, M. Resch-Beusher, E. Resel, D. Arnouil, D. Saraswat, M. Varilh, A. Cannich, F. Julio-Kalajzic, I. Bonilla-Del Río, A. Almeida, N. Puente, S. Achicallende, M.L. López-Rodríguez, C. Jollé, N. Déglon, L. Pellerin, C. Josephine, G. Bonvento, A. Panatier, B. Lutz, P.-V. Piazza, M. Guzmán, L. Bellocchio, A.-K. Bouzier-Sore, P. Grandes, J.P. Bolaños, G. Marsicano
Efficient chemoenzymatic synthesis of N-glycans with a beta-1,4-galactosylated bisecting GlcNAc motif
M. Weiss, D. Ott, T. Karagiannis, M. Weishaupt, M. Niemietz, S. Eller, M. Lott, M. Martínez-Orts, Á. Canales, N. Razi, J.C. Paulson, C. Unverzagt
Competitive upconversion-linked immunoassay using peptide mimetics for the detection of the mycotoxin zearalenone
R. Peltomaa, Z. Farka, M.J. Mickert, J.C. Brandmeier, M. Pastucha, A. Hlavá’ek, M. Martínez-Orts, Á. Canales, P. Skládal, E. Benito-Peña, M.C. Moreno-Bondi, H.H. Gorris